Since 2003 alongside allergists, hospitals and research

Less time on data.More time with patients.

TPS platforms collect, structure, and analyze allergy patient data: from electronic symptom diaries to specialist clinical records and decision support. Medical software co-designed with allergists, compliant with GDPR.

See the platforms
  • Over 20 years in digital allergology
  • 6 platforms and apps in clinical use
  • AllergyPlan in CE IIa certification
  • GDPR-compliant infrastructure
I segnali quotidiani del paziente vengono trasformati in un quadro clinico strutturato

2003

Year founded: an allergist and a computer engineer

6

Clinical platforms & apps in active use, not prototypes

6

Supported languages: Italian, English, German, French, Spanish, Portuguese

CE IIa

Medical device certification in progress for AllergyPlan

The problem

Allergy data is fragmented. And it carries a heavy cost.

Paper records, scattered PDFs across different folders, symptom diaries relying on patient memory, and unmeasured immunotherapy adherence. The result is a consultation that starts from scratch every time, non-comparable data, and clinical trials losing statistical power.

Paper-based history

Scattered PDF reports across different folders. Clinical history has to be reconstructed at every visit instead of simply consulted.

A diary held together by memory

Symptoms and medications recounted verbally in the clinic, not recorded the moment they happen.

Adherence nobody measures

No one really knows how closely a patient follows immunotherapy between one visit and the next.

Data that can't be compared

Free text instead of standardized scores: trials lose statistical power over data quality, not sample size.

About us

Founded by an allergist and an engineer, not a business plan

TPS Production was founded in Rome in 2003, where someone who saw the problem on the clinic floor — allergy data lost between one visit and the next — met someone who knew how to build the software to fix it.

Twenty years later the setup is the same: every platform comes from a request by someone who actually uses it in clinic, not from a product team far from the ward. We don't hand over software and step away — we stay alongside the allergists, hospitals and research groups we work with, through configuration and daily use alike.

A diary nobody fills in is useless to anyone: reducing the friction of logging was the first problem to solve, not the last.

The principle behind every screen we design

Who we serve

Four stakeholders, one unified data architecture

The same platforms address very different needs depending on who uses them. Here is what changes concretely for each.

Allergists & clinical centers

Arrive at visits with ready-to-use data

  • Patient-completed symptom and medication diary
  • Automated RTSS and Asthma Score calculations
  • SLIT adherence tracking over time
  • Direct doctor-patient communication
Hospitals & health systems

A specialist record that communicates with your systems

  • Multilingual allergology record (IT, EN, DE)
  • Back-office for the entire medical team
  • Telemedicine and remote monitoring
  • Modular architectures and cloud solutions
IVD & pharma enterprises

Your diagnostic tests inside the clinical pathway

  • Diagnostic panels integrated into reporting
  • Molecular diagnostics visualization
  • Aggregated and anonymized usage data
  • Customization and white-label options
Research & clinical trials

Structured datasets from day one

  • Standardized longitudinal data collection
  • Instant Excel export for statistical analysis
  • Treatment period cloning
  • Study design and AI-assisted analysis support

The platforms

Six tools covering the complete clinical and real-world pathway

From daily patient symptom tracking and immunotherapy adherence to clinical decision support. Each platform operates standalone and integrates with the others.

Visualizzazione del diario digitale AllergyMonitor
6 Languages (IT·EN·DE·FR·ES·PT) · Mobile app + web

AllergyMonitor

The electronic diary for allergy patients

Patients with allergic rhino-conjunctivitis and asthma record daily symptoms and medication intake with immediate graphical symbols. The physician receives a clinical back-office with real treatment trends, not a rushed waiting-room summary.

  • Daily or weekly logging
  • Pharmacological therapy & immunotherapy
  • Graphical analytics: RTSS and Asthma Score
  • Integrated doctor-patient chat
  • Available in 6 languages: IT, EN, DE, FR, ES, PT
  • iOS & Android apps with secure personal login
Visualizzazione della cartella clinica AllergyCard
Italian · English · German

AllergyCard

The allergist's specialist clinical record

Centralizes all allergy patient clinical information into a single screen. Diagnostic severity and reliability are legible at a glance with colored bars and circles. Navigation follows a mouse-driven tree structure with zero mandatory text fields.

  • Complete clinical history in a single view
  • Severity and reliability represented visually
  • Tree structure, mouse-driven data entry
  • Access to updated drug and allergen databases
  • Native multilingual interface
  • Fast entry compatible with clinic schedules
Visualizzazione del supporto decisionale AllergyPlan
CE Class IIa certification in progress

AllergyPlan

Data analysis and clinical decision support

The intelligent platform combining data streams from the others and interpreting them. Artificial intelligence algorithms support the clinician without replacing professional judgement: the recommendation remains a suggestion, responsibility stays with the physician. Currently undergoing CE Class IIa certification as a medical device.

  • Integrated patient data synthesis
  • Algorithmic diagnostic support
  • Medical device certification pathway
  • Designed for IVD diagnostic integration
Visualizzazione della valutazione digitale ScoradCard
Version 2.0

ScoradCard

SCORAD calculated by sketching on screen

In atopic dermatitis, estimating lesion extent is subjective, slow, and hard to reproduce across clinicians. ScoradCard solves this by letting clinicians sketch lesions directly on a digital anatomical model, automatically calculating body surface area and generating the SCORAD score.

  • Direct sketching on the digital body model
  • Automated lesion surface calculation
  • SCORAD score generated and stored
  • Longitudinally comparable evaluations
Visualizzazione del monitoraggio terapeutico SlitMonitor
Mobile app iOS & Android

SlitMonitor

The specialized diary for Sublingual Immunotherapy (SLIT)

Dedicated application for patients undergoing Sublingual Immunotherapy. Enables precise daily intake recording, tracking of local/systemic adverse reactions, and long-term adherence monitoring, providing the specialist with a reliable clinical history.

  • Daily SLIT intake recording
  • Local & systemic reaction tracking
  • Longitudinal adherence analytics
  • Custom reminders and notifications
  • Direct data sharing with the allergist
  • Native app for iOS and Android
Visualizzazione della mappa collaborativa PollenTrace
Mobile app & Geotagging

PollenTrace

Real-time collaborative mapping of pollen allergy symptoms

Citizen-science mobile platform for patients with allergic rhinitis. Enables real-time well-being ratings on a Visual Analogue Scale (VAS) with anonymous geotagging, creating an interactive map of pollen impact across territories.

  • Instant Visual Analogue Scale (VAS) rating
  • Interactive map with anonymous geotagging
  • Correlation with pollen count calendars
  • Community-driven territorial monitoring
  • Personal symptom tracking history
  • Available on App Store and Google Play

Research and publications

Our platforms in the scientific literature

Since 2004, TPS Production technologies have been the data collection instrument of clinical studies published in international peer-reviewed journals. Here is the verifiable list, with a PubMed link for every paper.

  • 23 peer-reviewed publications
  • 12 international journals
  • 2004–2026
  • 8E-diary
  • 3Predictive algorithms
  • 6Molecular allergology
  • 4Pollen exposure
  • 2Atopic dermatitis

Open an entry to read its summary.

2026The Journal of Allergy and Clinical ImmunologyEtiologic diagnosis of seasonal allergic rhinitis supported by artificial intelligence: The @IT-2020 project.Matricardi PM, Monnati F, Palmieri L et al.

A machine-learning clinical decision support system identifies the culprit pollen in seasonal allergic rhinitis, reproducing expert diagnosis with an AUC above 95%. Its three progressive modules combine clinical history and skin prick tests, molecular sIgE and the electronic diary.

2026Clinical and Experimental AllergyEarly Detection of Lower Adherence to Long-Term e-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis?Dramburg S, Hernandez Toro CJ, Grittner U et al.

Across 815 patients in seven Mediterranean countries, the e-diary prescribed by the allergist reached an average completion rate of 75.2% over a mean 106-day period. The study identifies early determinants of attrition that can target educational intervention.

2024AllergyDigitally-enabled, person-centred care (PCC) in allergen immunotherapy: An ARIA-EAACI Position Paper.Pfaar O, Sousa-Pinto B, Papadopoulos NG et al.

A joint ARIA-EAACI position paper on mHealth apps in allergen immunotherapy: patient selection, early and late efficacy assessment, stopping rules. AllergyMonitor is among the few solutions backed by published scientific evidence.

Show all 23 publications
2024AllergyHeterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries - The @IT.2020 multicenter study.Dramburg S, Grittner U, Potapova E et al.

Sensitization profiles and clinical phenotypes of 348 children and 467 adults with seasonal allergic rhinitis, recruited with a uniform methodology across nine cities in seven Southern European countries.

2023Frontiers in AllergyFactors predicting the outcome of allergen-specific nasal provocation test in children with grass pollen allergic rhinitis.Barreto M, Tripodi S, Arasi S et al.

Clinical data, molecular sIgE and e-diary outcomes recorded through the pollen season are used to predict the result of the nasal provocation test in poly-sensitized children.

2023Allergologie SelectReal-life evidence in allergen immunotherapy: Moving forward with mHealth apps.Sousa-Pinto B, Pfaar O, Bousquet J

A review of the mHealth apps usable to collect real-world data on allergen immunotherapy: of the five with scientific publications, only MASK-air and AllergyMonitor cover patients under immunotherapy.

2023AllergyProspective (e-diary) vs retrospective (ARIA) measures of severity in allergic rhinoconjunctivitis: An observational compatibility study.Dramburg S, Perna S, Di Fraia M et al.

A comparison between severity measured day by day with the e-diary and severity reconstructed retrospectively with the ARIA classification: two measures that do not coincide in clinical practice.

2022Clinical and Translational AllergyReal-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities.Sousa-Pinto B, Anto A, Berger M et al.

Of more than 1,500 rhinitis and rhinosinusitis apps surveyed in the app stores, only six have published results in the scientific literature. AllergyMonitor is one of them.

2022JMIR mHealth and uHealthValidation Parameters of Patient-Generated Data for Digitally Recorded Allergic Rhinitis Symptom and Medication Scores in the @IT.2020 Project: Exploratory Study.Dramburg S, Perna S, Di Fraia M et al.

Identifies the parameters that estimate the intrinsic quality of patient-entered data beyond mere recording completeness — a prerequisite for relying on the diary in clinical decisions.

2021Clinical and Translational AllergyHeterogeneous validity of daily data on symptoms of seasonal allergic rhinitis recorded by patients using the e-diary AllergyMonitor®.Dramburg S, Perna S, Di Fraia M et al.

Analysis of the consistency between symptom and medication scores in 101 children and 93 adults recording daily data with AllergyMonitor: validity holds at population level but varies from patient to patient.

2021AllergyHeterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study.Lipp T, Acar Sahin A, Aggelidis X et al.

Among 815 patients with seasonal allergic rhinitis, 20.5% report pollen food allergy syndrome reactions, most often triggered by kiwi, peach and melon.

2020PLoS OneA study of longitudinal mobile health data through fuzzy clustering methods for functional data: The case of allergic rhinoconjunctivitis in childhood.Giordani P, Perna S, Bianchi A et al.

A fuzzy clustering method for functional data applied to longitudinal mobile health series, to identify patient clusters on which differentiated therapies can be built.

2020Italian Journal of PediatricsDigital technologies for an improved management of respiratory allergic diseases: 10 years of clinical studies using an online platform for patients and physicians.Tripodi S, Giannone A, Sfika I et al.

A synthesis of ten years of clinical studies and routine practice with AllergyMonitor (TPS, Rome) since 2009: etiologic diagnosis by matching symptoms with pollen counts, short-term symptom prediction, adherence measurement.

2020Journal of Medical Internet ResearchAdherence to Prescribed E-Diary Recording by Patients With Seasonal Allergic Rhinitis: Observational Study.Di Fraia M, Tripodi S, Arasi S et al.

Adherence to an e-diary prescribed by the allergist within a blended care pathway is far higher than that observed for spontaneously downloaded apps. Cohort of 101 children and 93 adults.

2020Allergy"Whole" vs. "fragmented" approach to EAACI pollen season definitions: A multicenter study in six Southern European cities.Hoffmann TM, Acar Sahin A, Aggelidis X et al.

EAACI pollen season definitions, designed for Northern Europe, fragment into up to eight segments across the six Mediterranean cities analysed — a direct problem for immunotherapy trial design.

2019Pediatric Allergy and ImmunologyEarly molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.Cipriani F, Tripodi S, Panetta V et al.

401 children from the "Panallergens in Pediatrics" cohort re-examined six years later; the structured clinical history was collected with AllergyCARD at both baseline and follow-up.

2018AllergyDiagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules.Cipriani F, Mastrorilli C, Tripodi S et al.

1,120 children with grass pollen rhinoconjunctivitis, standardized questionnaires acquired through AllergyCARD: 87 distinct sensitization profiles across the eight Phleum pratense molecules.

2016Pediatric Allergy and ImmunologyComparison of six disease severity scores for allergic rhinitis against pollen counts: a prospective analysis at population and individual level.Florack J, Brighetti MA, Perna S et al.

Six severity scores compared against pollen counts in cohorts from Ascoli and Berlin: the platform automatically generates one symptom score and five symptom-medication scores from the same data.

2014European Annals of Allergy and Clinical ImmunologyPilot study on the short-term prediction of symptoms in children with hay fever monitored with e-Health technology.Costa C, Menesatti P, Brighetti MA et al.

A 15-variable predictive model (date, weather, airborne concentration of five pollen taxa, IgE sensitization intensity) forecasting the individual patient's symptoms in the short term.

2014Clinical and Experimental AllergyThe impact of telemonitoring on adherence to nasal corticosteroid treatment in children with seasonal allergic rhinoconjunctivitis.Pizzulli A, Perna S, Florack J et al.

A randomized controlled trial: children followed with AllergyMonitor telemonitoring versus usual care with no diary. Adherence to nasal corticosteroid was measured by weighing the canisters, not self-reported.

2013Pediatric Allergy and ImmunologyPollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity.Dondi A, Tripodi S, Panetta V et al.

1,360 children recruited across 16 pediatric allergy clinics in 14 Italian cities, with standardized atopy questionnaires collected on the platform: prevalence and determinants of pollen-induced rhinitis severity.

2005Pediatric Allergy and ImmunologyComputer aided design mapping for SCORAD index in atopic dermatitis: ScoradCard software.Tripodi S

Description of the ScoradCard software for computer-aided lesion mapping in the calculation of the SCORAD index in atopic dermatitis.

2004Pediatric Allergy and ImmunologyMeasurement of body surface area in atopic dermatitis using specific PC software (ScoradCard).Tripodi S, Panetta V, Pelosi S et al.

Twenty pediatricians untrained in skin assessment estimated the involved body surface area first by sight, then with ScoradCard: by sight the estimate deviates from the gold standard, with the software it does not.

Our approach

Four principles behind every platform

Continuous data, not snapshots

The patient tracks symptoms and medications between visits. The physician enters the clinic with the longitudinal curve already plotted, not a reconstructed story.

Structure, not free text

Standardized scores, diagnostic trees, and severity scales. Everything entering the system is comparable across patients, centers, and over time.

Built with practitioners

Every screen stems from an allergist's request. No mandatory fields beyond demographics: the software adapts to the rhythm of the visit, not vice versa.

Compliance by design

Data processing designed according to GDPR, and HIPAA where required. Security is not an afterthought.

Security & compliance

Clinical data stays where it belongs

We don't treat data protection as a feature bolted on at the end. It's part of the architecture from the first line of code.

GDPR by design

Processing of personal and health data is designed according to EU Regulation 2016/679 from the architecture up, not added afterwards.

HIPAA where required

In contexts that require it, the data processing setup is also compliant with HIPAA standards for health data protection.

Ownership stays with the provider

Clinical data remains under the exclusive ownership of the hospital, clinic or center that collects it. TPS acts as data processor, not data controller.

AllergyPlan in CE IIa certification

The decision-support platform is currently undergoing certification as a medical device under the European MDR regulation.

Updated regulatory documentation for each product is available on request.

How it is adopted

From analysis to daily practice

We don't hand over a license and wish you luck. Adoption is a supported journey, calibrated to your way of working.

01

Analysis

We map your actual clinical workflow and existing legacy software to see where data is currently lost.

02

Configuration

We configure platforms around your protocols, assessment scales, and institutional terminology.

03

Hands-on Launch

Medical team training, onboarding of first patients, and real-time adjustments during initial weeks.

04

Evolution

Periodic analytical reports, new feature rollouts, and ongoing support as your usage expands.

Beyond the platforms

When you need something that doesn't exist yet

The exact same engineering and clinical expertise that built our products is available as a professional service.

Custom Software Development

Web applications, mobile apps, and digital healthcare platforms for patient monitoring, telemedicine, and EMRs—designed from day one for GDPR and HIPAA compliance.

Data Science, Biostatistics & AI Models

We transform clinical datasets and telemetric streams into actionable scientific evidence and predictive algorithms. We assist research teams and pharma enterprises with advanced biostatistical analytics, longitudinal time-series structuring, and training and validating machine learning and AI models on real-world patient cohorts.

IT & Infrastructure Consulting

Redesign of hospital IT infrastructure, secure cloud solutions, database optimization, and modular software architectures.

Clinical Trial Consulting

Support with study design, standardized data collection, and research protocol management, generating robust Real-World Evidence (RWE) with AI-assisted statistical analytics.

Frequently asked questions

The questions we receive before getting started

Are the platforms certified medical devices?

AllergyPlan is currently in the formal CE Class IIa certification process as a medical device. Other platforms serve as clinical data collection, telemetry, and visualization tools supporting physician workflows without making autonomous diagnoses. Full regulatory documentation is available upon request.

How is patient data handled and protected?

Data processing is designed according to GDPR from the core architecture, and HIPAA where required. Each patient logs in with personal credentials and clinical data remains under the exclusive ownership of the treating healthcare institution.

Do the platforms integrate with existing systems?

Yes. We develop modular architectures and offer healthcare interoperability consulting. Integration scope depends on what your existing software exposes, which is assessed during the analysis phase.

How long does implementation take?

It depends on scope. A single allergology clinic starting with AllergyMonitor or SlitMonitor can be operational in a few days. A hospital integration with multiple departments requires a structured analysis and deployment plan.

Do patients actually manage to use the diary?

Yes—this was our primary design requirement. Symptom logging uses intuitive visual icons and takes under 45 seconds daily. Reducing recording friction was our very first problem to solve.

Do you collaborate with IVD diagnostic and pharmaceutical companies?

Yes. Our platforms provide the exact touchpoint where diagnostic test results translate into clinical decisions. We evaluate custom integrations, specialized modules, and white-label solutions on a case-by-case basis.

Let's talk

Tell us how you work today

Whether you are an outpatient clinic, a hospital management team, a diagnostic enterprise, or a research group, the starting point is the same: identifying where data gets lost. Write to us and we will respond promptly.

Direct contact form

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TPS Production

Direct contact form

Headquarters

Via Nomentana 352 00141 Rome, Italy

Phone

+39 06 9835 9388Mon-Fri 09:00 - 17:00

From first message to next step

A clear request deserves an equally practical response.

  1. 1We review your requirements, workflows, and context
  2. 2We involve the TPS person best suited to the topic
  3. 3We arrange a focused conversation or demo